CHAMPION-AF Survival Simulator

EHR Research Tool

Reproduce & stress-test CHAMPION-AF (ACC 2026) results — simulate how differential follow-up and censoring bias survival estimates between LAAC and NOAC arms

LAAC Watchman FLX arm
True annual event rate1.96%
0.2%10%
Clinic visits / year3.0
0.512

LAAC: 45-day, 6-mo, annual device checks

Max follow-up (years)3.0
Loss to follow-up (%/yr)3%
Sample size400
NOAC Oral anticoagulation arm
True annual event rate1.63%
0.2%10%
Clinic visits / year1.0
0.512

NOAC: annual in-office (phone visits miss events)

Max follow-up (years)3.0
Loss to follow-up (%/yr)5%
Sample size400
Global Settings
Weibull shape1.0
0.5 (decr.)3 (incr. hazard)

Observed HR (LAAC/NOAC)

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95% CI: —

HR Bias from detection

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obs − true ratio

LAAC detection rate

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events caught / occurred

NOAC detection rate

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events caught / occurred

Observed Kaplan-Meier Curves

LAAC NOAC

Event Detection: True vs Observed Rates

HR Distribution (across runs)

Event Summary (last run)
Run simulation to see event summary.

CHAMPION-AF Context

Adjust parameters and click Run Simulation to see how differential follow-up between LAAC and NOAC affects observed hazard ratios.

Detailed Statistics

Log-rank p

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LAAC events

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NOAC events

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Missed events (LAAC)

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Missed events (NOAC)

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CHAMPION-AF: N Engl J Med 2026 | Simulation: visit-based event ascertainment model | luna clinical research agent